Why obese people with fatty liver?

Fatty liver is more common in obese people as a complication of many obese people after a super-B and liver aspiration inspection found that often occurred in the liver steatosis, while there have been severe fatty liver. Liver tissue examination showed that: about 50% of the combined fatty liver, especially abdominal obesity occurred in people more opportunities for fatty liver. Why?

Originally, the normal liver contains only a small amount of fat, about 4% - 7%. This is a small amount of fat in the half for the neutral fats (triglycerides), for the rest of the PC and a small amount of cholesterol. Synthesis of fatty liver is neutral and use of the main organs, not fat storage sites. Liver will continue to enter the synthesis of fatty acids in the liver triglyceride, and soon a new synthesis of triglycerides in lipoprotein (mainly very low density lipoprotein) in the form of release into the blood circulation. But when the liver's synthesis of triglycerides and operation of the imbalance, a large number of neutral fat in the liver can be formed when the accumulation of fatty liver.

Abdominal fat people are prone to fatty liver, because the fat around the abdomen to stimulate the cells to a more sensitive, resulting in abdominal fat by the liver cells to be transmitted to the increase in fatty acids. Fatty liver in addition to the blocked part of the synthesis of cholesterol and phospholipids, the major synthetic triglycerides, triglyceride synthesis of new liver cells with rough endoplasmic reticulum of the synthetic APO, the formation of VLDL ─ ─ triglycerides Ester released into the blood when the liver's synthesis of triglycerides in liver more than its ability to transfer out, or the formation of VLDL output took place obstacles can lead to accumulation of triglycerides in the liver and fatty liver occurred.

In addition, the number of obese people have impaired glucose tolerance and hyperinsulinemia in obesity prevalence of fatty liver played an important role. Surrounding tissue as a result of lower insulin sensitivity, the ability of muscle glucose uptake was also reduced, so that glucose can not fully be used, the excess glucose continuously to stimulate a large number of insulin-secreting islet cells.

The role of insulin in the liver, glucose and fatty acid synthesis of a large number of triglycerides, and subsequent endogenous fatty liver and hyperlipidemia.

As a result, obese patients with abdominal obesity in particular, patients should actively cooperate with the weight loss treatment, fundamentally the prevention and treatment of fatty liver.